Changed gene expression in subjects with schizophrenia and low cortical muscarinic M1 receptors predicts disrupted upstream pathways interacting with that receptor

E Scarr; M Udawela; EA Thomas; B Dean

Journal article

Changed gene expression in subjects with schizophrenia and low cortical muscarinic M1 receptors predicts disrupted upstream pathways interacting with that receptor

E Scarr, M Udawela, EA Thomas, B Dean

Molecular Psychiatry | NATURE PUBLISHING GROUP | Published : 2018

DOI: 10.1038/mp.2016.195

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Abstract

We tested the hypothesis that, compared with subjects with no history of psychiatric illness (controls), changes in gene expression in the dorsolateral prefrontal cortex from two subgroups of subjects with schizophrenia, one with a marked deficit in muscarinic M1 receptors (muscarinic receptor-deficit schizophrenia (MRDS)), would identify different biochemical pathways that would be affected by their aetiologies. Hence, we measured levels of cortical (Brodmann area 9) mRNA in 15 MRDS subjects, 15 subjects with schizophrenia but without a deficit in muscarinic M1 receptors (non-MRDS) and 15 controls using Affymetrix Exon 1.0 ST arrays. Levels of mRNA for 65 genes were significantly different ..

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University of Melbourne Researchers

Brian Dean Author Florey Department of Neuroscience and Mental Health

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Awarded by National Science Foundation

Funding Acknowledgements

We gratefully acknowledge Geoff Pavey for his technical assistance and curation of the human brain tissue. This project was supported by the National Health and Medical Research Council (Australia; Project Grant 566967, Fellowship (BD) APP1002240), the Australian Research Council (Fellowship (ES) FT100100689) and the Victorian Government's Operational Infrastructure Support Programme. Tissue was sourced from the Victorian Brain Bank, supported by the Mental Health Research Institute, The Alfred, Victorian Forensic Institute of Medicine, The University of Melbourne and funded by Australia's National Health & Medical Research Council, Helen Macpherson Smith Trust, Parkinson's Victoria and Perpetual Philanthropic Services.